A general approach for the asymmetric synthesis of densely substituted piperidines and fully substituted piperidinones employing the asymmetric Mannich reaction as key step

Article abstract of DOI:10.1039/c3ra45110k

Two efficient and alternative protocols for the preparation of highly enantioenriched piperidine structures are reported. We have also developed a simple route to access to fully diastereo- and enantioenriched substituted piperidinones. The key step of al