A New Approach to the Design of ?-2-Selective Ligands: Synthesis and Evaluation of N--N-methyl-2-(1-pyrrolidinyl)ethylamine-Related Polyamines at ?-1 and ?-2 Receptor Subtypes

DOI: 10.1021/jm00028a016

Source and publish data:

Journal of Medicinal Chemistry p. 314 - 321 (1994)

Update date:2022-09-26

Topics:

Authors:

Costa, Brian R. de

He, Xiao-shu

Dominguez, Celia

Cutts, Janet

Williams, Wanda

Bowen, Wayne D.

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Article abstract of DOI:10.1021/jm00028a016

A series of polyamines based on the high affinity ? receptor ligand N-<2-(3,4-dichlorophenyl)ethyl>-N-methyl-2-(1-pyrrolidinyl)ethylamine (3) were developed and evaluated for their binding characteristics at ?-1 and ?-2 receptor subtypes.The data indicate

Full text of DOI:10.1021/jm00028a016

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Product name:{[[2-(3,4-Dichloro-phenyl)-ethyl]-(2-pyrrolidin-1-yl-ethyl)-carbamoyl]-methyl}-carbamic acid tert-butyl ester

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