SYNTHESIS OF N-(2-DEOXY-β-D-RIBOSYL) 4-THIOMETHYLINDOLE: A PURINE SURROGATE FOR INCORPORATION INTO OLIGONUCLEOTIDES.

Article abstract of DOI:10.1016/S0040-4039(00)91816-1

Efficient, high-yielding syntheses of S-acetyl-N-(2-deoxy-β-D-ribosyl) 4-thiomethylindole (9) and the corresponding 5'-O-trityl-3'-O-phosphoramidite ester 11 are reported, suitable for direct incorporation into oligodeoxynucleotides by standard solid-phas