Chiral piperazines as catalysts for the enantioselective addition of diethylzinc to aldehydes

DOI: 10.1248/cpb.41.1557

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1557 - 1561 (1993)

Update date:2022-08-03

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Authors:

Fuji Fuji

Tanaka Tanaka

Miyamoto

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Article abstract of DOI:10.1248/cpb.41.1557

Enantioselective ethylation of benzaldehyde with diethylzinc in the presence of a catalytic amount of chiral piperazine derivatives was investigated. The chiral piperazine works as an asymmetric catalyst in the alkylation, yielding 1-phenylpropanol with a moderate enantioselectivity. The influence of structural variation of the piperazine ring upon the asymmetric induction and the mechanism involved are discussed.

Full text of DOI:10.1248/cpb.41.1557

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