Synthesis of (±)-N2-(benzenesulfonyl)-CPI, the protected A-unit of the antitumor antibiotic CC-1065, by two metal-initiated cyclizations

DOI: 10.1021/jo00080a031

Source and publish data:

Journal of Organic Chemistry p. 192 - 196 (1994)

Update date:2022-08-02

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Authors:

Tietze Tietze

Grote Grote

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Article abstract of DOI:10.1021/jo00080a031

A new synthetic route to (±)-N²-(Benzenesulfonyl)-CPI (16), the protected A-unit containing a cyclopropylhexadienone moiety of the highly potent antitumor antibiotic CC-1065 (1), from 5-(benzyloxy)-2- bromophenylamine (3) is described. The key

Full text of DOI:10.1021/jo00080a031

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