Journal of Medicinal Chemistry p. 371 - 380 (1994)
Update date:2022-09-26
Topics:
Atwell, Graham J.
Sykes, Bridget M.
O'Connor, Charmian J.
Denny, William A.
2-Nitroaryl amides of general structure I are proposed as bioreducible prodrugs, capable of releasing cytotoxic aminoaniline mustards V on bioactivation by spontaneous cyclization of the resulting 2-aminoaryl amides II via a tetrahedral intermediate, III.
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(1994)
