Tetrahedron Asymmetry p. 2967 - 2974 (1997)
Update date:2022-07-29
Topics:
Alcon, Montserrat
Poch, Marta
Moyano, Albert
Pericas, Miquel A.
Riera, Antoni
An asymmetric synthesis of fully protected (S)-Vigabatrin has been developed. The key intermediate in the sequence is enantiomerically pure N-Boc-5-phenyl-3-amino-1,2-diol 5a, obtained from (E)-5-phenyl-2-penten-1-ol by employing a catalytic Sharpless epo
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