Asymmetric syntheses of (2r,4s)-4-amino-4-carboxy-2-methylpyrrolidine and (2r, 4s)-4-amino-2-carboxy-2-ethyl-pyrrolidine as novel 2-alkyl-substituted (-)-cucurbitine analogues

Article abstract of DOI:10.3987/COM-95-7277

Asymmetric syntheses of (2R,4S)-4-amino-4-carboxy-2-methylpyrrolidine (1) and (2R, 4S)-4-amino-4-carboxy-2-ethylpyrrolidine (2) as 2-alkyl-substituted (-)-cucurbitine analogues, have been achieved without disturbing C₂ stereogenic center throug