ASYMMETRIC SYNTHESIS OF THE ANTICOCCIDIAL ANTIBIOTIC DIOLMYCIN A1. DETERMINATION OF ABSOLUTE STEREOCHEMISTRY

Article abstract of DOI:10.1016/S0040-4039(00)61668-4

An asymmetric total synthesis of diolmycin A1 (1), a recently discovered anticoccidial antibiotic, has been achieved in six steps from 2-(4-hydroxyphenyl)ethanol.The natural product comprises an unusual ca. 4:1 mixture of enantiomers; the synthesis defined the (11R,12S) absolute configuration of the predominant (-) antipode.