
Tetrahedron Letters p. 6659 - 6660 (1993)
Update date:2022-08-05
Topics:
Sunazuka, Toshiaki
Tabata, Noriko
Nagamitsu, Tohru
Tomoda, Hiroshi
Omura, Satoshi
Smith, Amos B.
An asymmetric total synthesis of diolmycin A1 (1), a recently discovered anticoccidial antibiotic, has been achieved in six steps from 2-(4-hydroxyphenyl)ethanol.The natural product comprises an unusual ca. 4:1 mixture of enantiomers; the synthesis defined the (11R,12S) absolute configuration of the predominant (-) antipode.
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