3,3,3-Trifluoro-2-isocyanopropionates, new versatile building blocks for the introduction of trifluoromethyl groups into organic molecules

Article abstract of DOI:10.1016/S0022-1139(00)80487-X

α-Trifluoromethyl-substituted α-amino acid esters 1 give N-formyl α-trifluoromethyl α-amino acid esters 2 on reaction with formic acid/acetic anhydride. 3,3,3-Trifluoro-2-isocyanopropionates 3 are obtained from 2 upon treatment with diphosgene/triethylami