Journal of Organic Chemistry p. 1771 - 1778 (1994)
Update date:2022-08-03
Topics:
Fletcher, Stephen R.
Baker, Raymond
Chambers, Mark S.
Herbert, Richard H.
Hobbs, Sarah C.
et al.
The synthesis of (+)- and (-)-epibatidine (exo-2-(2-chloropyridin-5-yl)-7-azabicyclo<2.2.1>heptane) via reaction of 5-lithio-2-chloropyridine with (+)- and (-)-N-BOC-7-azabicyclo<2.2.1>heptan-2-one is described.The absolute configuration of the natural product is shown to be 1R,2R,4S.
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Doi:10.1002/prac.19943360206
(1994)Doi:10.1021/acs.orglett.5b02263
(2015)Doi:10.1055/s-0035-1561667
(2016)Doi:10.1016/j.tet.2013.12.019
(2014)Doi:10.1016/S0040-4039(00)73041-3
(1994)Doi:10.7164/antibiotics.47.262
(1994)
