Synthesis of (2R,5S)- and (2S,5S)-2-carboxy-1,4-diaza[4.3.0]bicyclononane as building blocks for the synthesis of new potential HIV protease inhibitors

Article abstract of DOI:10.1016/0957-4166(96)00241-8

A procedure for the preparation of optically active (2R,5S)- and (2S,5S)-2-carboxy-1,4-diaza-[4.3.0]bicyclononane is described. The method is based on the reduction of diketopiperazines obtained from cyclization of Pro-L-Ser or Pro-D-Ser and occurs withou