Synthetic Studies on the Proposed Spiro Intermediate for Biosynthesis of the Natural Porphyrins: Inhibition of Cosynthetase

DOI: 10.1039/c39860000465

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Journal of the Chemical Society. Chemical communications p. 465 - 467 (1986)

Update date:2022-07-29

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Authors:

Stark, W. Marshall

Hart, Graham J.

Battersby, Alan R.

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Article abstract of DOI:10.1039/c39860000465

A macrocyclic spiro-lactam is synthesised which closely resembles the spiro system proposed as a biosynthetic intermediate for uro'gen-III; this spiro-lactam powerfully inhibits cosynthetase, the enzyme responsible for forming uro'gen-III.

Full text of DOI:10.1039/c39860000465

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