Synthetic Studies on the Proposed Spiro Intermediate for Biosynthesis of the Natural Porphyrins: Inhibition of Cosynthetase

DOI: 10.1039/c39860000465

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 465 - 467 (1986)

Update date:2022-07-29

Topics:

Authors:

Stark, W. Marshall

Hart, Graham J.

Battersby, Alan R.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1039/c39860000465

A macrocyclic spiro-lactam is synthesised which closely resembles the spiro system proposed as a biosynthetic intermediate for uro'gen-III; this spiro-lactam powerfully inhibits cosynthetase, the enzyme responsible for forming uro'gen-III.

Full text of DOI:10.1039/c39860000465

View Article Online / Journal Homepage / Table of Contents for this issue

View Article Online

Products guided by the article

Product name:4-[5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-3-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,7-bis-(2-methoxycarbonylethyl)-3,8-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin-1(10H)-one

Cas No:155434-89-2

R&D Labs maybe for 155434-89-2

Nanjing distinctions Medical Technology Co., Ltd.(expird)

Contact:+86-15996203785 13914714059

Address:nanjing,jiangsu , China
Beijing Mashi Fine Chemical Co.,Ltd.

Contact:+86-10-61271592

Address:Room 506, Section B, Kaichi Mansion, Industrial Development
Luoyang Aoda chemical Co.,Ltd.

Contact:+86-379-67518785 67516588

Address:MiaoWan industry district,YanShi City,Henan,China
Hebei DaPeng Pharm & Chem Co., Ltd.

Contact:86-317-7298678,0576-88861898 88861908

Address:West Songmen Village, East Songmen Town, Wuqiao, Cangzhou, Hebei ,China
Shandong Loyal Chemical industrial Co.,Ltd

Contact:0533-7451788

Address:Linzi Chemical Industrial Park, Zibo, Shandong Province

Relevant to this article

Two-Step Stereoselective Conversion of 5-Monosubstituted 1,3-Dioxolan-4-ones into Selectively Protected 2,3-Erythro-1,2,3-Triols. A Route to Polyhydroxylated Molecules

Doi:10.1016/S0040-4039(00)77164-4
(1994)
A flexible, highly efficient method for the preparation of homochiral oxazaphospholidine-boranes

Doi:10.1016/S0040-4020(01)80637-2
(1994)
Substrates as Electron-Donor Precursors: Synthesis of Naphtho-Fused Oxindoles via Benzannulation of 2-Halobenzaldehydes and Indolin-2-ones

Doi:10.1021/acs.orglett.6b02515
(2016)
Total synthesis of 7′-desmethylkealiiquinone, 4′- desmethoxykealiiquinone, and 2-deoxykealiiquinone

Doi:10.1021/jo4027337
(2014)
Catalytic asymmetric Exo-selective [C+NC+CC] reaction

Doi:10.1021/ol500474a
(2014)
Copper porphyrin as efficient catalysts for esterification of allyl sp³ C–H bond with carboxylic acid

Doi:10.1016/j.catcom.2019.04.001
(2019)

Article Doi