Synthetic Studies on the Proposed Spiro Intermediate for Biosynthesis of the Natural Porphyrins: Inhibition of Cosynthetase

DOI: 10.1039/c39860000465

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 465 - 467 (1986)

Update date:2022-07-29

Topics:

Authors:

Stark, W. Marshall

Hart, Graham J.

Battersby, Alan R.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1039/c39860000465

A macrocyclic spiro-lactam is synthesised which closely resembles the spiro system proposed as a biosynthetic intermediate for uro'gen-III; this spiro-lactam powerfully inhibits cosynthetase, the enzyme responsible for forming uro'gen-III.

Full text of DOI:10.1039/c39860000465

View Article Online / Journal Homepage / Table of Contents for this issue

View Article Online

Products guided by the article

Product name:4-[5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-3-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,7-bis-(2-methoxycarbonylethyl)-3,8-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin-1(10H)-one

Cas No:155434-89-2

R&D Labs maybe for 155434-89-2

Beijing Wisdom Chemicals Co., Ltd.

Contact:+86-10-52350335

Address:F2, BLDG 19, Liando Valley U, Majuqiao, Tongzhou District, Beijing, China
Maithili Life Sciences

Contact:+91 9963263336

Address:Plot#146A, IDA Mallapur, Hyderabad - 500072
Shanghai Longschem Co.,Ltd

Contact:021-36356756

Address:Room601,Building No.14,280 Yangcheng Road,Shanghai
shandong lukang animal & plant drug trading co.,ltd.

Contact:15853765968

Address:floor 9, lukang ,jingying building,#173,taibai building west road,jining city,shandong,china
Suzhou CarbonWell Pharma-Tech Co., Ltd

Contact:Tel: + 86 (0)512-8898-1216; + 86-18606258602

Address:2358 Changan Road, Wujiang Scientific Innovation Park, Wujiang, Jiangsu Province, P. R. China 215200

Relevant to this article

Two-Step Stereoselective Conversion of 5-Monosubstituted 1,3-Dioxolan-4-ones into Selectively Protected 2,3-Erythro-1,2,3-Triols. A Route to Polyhydroxylated Molecules

Doi:10.1016/S0040-4039(00)77164-4
(1994)
A flexible, highly efficient method for the preparation of homochiral oxazaphospholidine-boranes

Doi:10.1016/S0040-4020(01)80637-2
(1994)
Substrates as Electron-Donor Precursors: Synthesis of Naphtho-Fused Oxindoles via Benzannulation of 2-Halobenzaldehydes and Indolin-2-ones

Doi:10.1021/acs.orglett.6b02515
(2016)
Total synthesis of 7′-desmethylkealiiquinone, 4′- desmethoxykealiiquinone, and 2-deoxykealiiquinone

Doi:10.1021/jo4027337
(2014)
Catalytic asymmetric Exo-selective [C+NC+CC] reaction

Doi:10.1021/ol500474a
(2014)
Copper porphyrin as efficient catalysts for esterification of allyl sp³ C–H bond with carboxylic acid

Doi:10.1016/j.catcom.2019.04.001
(2019)

Article Doi