Search for the pharmacophore of bispyridinium-type allosteric modulators of muscarinic receptors

DOI: 10.1021/jm00036a008

Source and publish data:

Journal of Medicinal Chemistry p. 1439 - 1445 (1994)

Update date:2022-08-04

Topics:

Authors:

Cid Cid

Holzgrabe

Kostenis

Mohr Mohr

Trankle Trankle

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Article abstract of DOI:10.1021/jm00036a008

The bis(dichlorobenzyl) ether of the bispyridinium oxime TMB 4 stabilizes antagonist binding to M₂-cholinoceptors which is indicative of an allosteric action. More than 10 derivatives of the lead compound were synthesized to investigate structu

Full text of DOI:10.1021/jm00036a008

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Product name:pyridine-4-carboxaldehyde (E)-O-(2,6-dichlorobenzyl)oxime

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