Synthesis of an unnatural product - 4,4′ biaryl formation as a macrocyclisation step

DOI: 10.1016/0040-4039(94)85086-0

Source and publish data:

Tetrahedron Letters p. 481 - 484 (1994)

Update date:2022-08-03

Topics:

Authors:

Patel, Hitesh K.

Kilburn, Jeremy D.

John Langley

Edwards, Peter D.

Mitchell, Tim

Southgate, Robert

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Article abstract of DOI:10.1016/0040-4039(94)85086-0

A novel macrocycle featuring a crown ether ring, amide functionality and a rigid biaryl unit has been prepared as a potential receptor for small peptidic guests. The synthesis of the macrocycle includes a palladium catalysed biaryl formation as the ring-closing step.

Full text of DOI:10.1016/0040-4039(94)85086-0

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Product name:{[4-(4-Bromo-benzyloxy)-benzylcarbamoyl]-methyl}-carbamic acid tert-butyl ester

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