A New Enantioselective Synthesis of trans 2,5-Disubstituted Pyrrolidine Derivatives by Radical Cyclisation

DOI: 10.1039/c39940000455

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Journal of the Chemical Society. Chemical communications p. 455 - 456 (1994)

Update date:2022-07-29

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Authors:

Yuasa, Yoko

Ando, Jun

Shibuya, Shiroshi

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Article abstract of DOI:10.1039/c39940000455

A new and highly enantioselective synthesis of trans 5-substituted 2-hydroxymethylpyrrolidine derivatives is achieved by intramolecular radical cyclization at the 4-position of Δ^4,5-oxazolidin-2-one, which leads to C₂-symmetrical 2,5-dibenzyloxypyrrolidin-2-one.

Full text of DOI:10.1039/c39940000455

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