Synthesis, stereochemistry, and opioid receptor binding activity of heterocyclic analogues of BW373U86

Article abstract of DOI:10.1002/jhet.5570320622

The synthesis of a series of heterocyclic analogues of (±)-4-((αR*)-α-((2S*,5R*)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- hydroxybenzyl)-N,N-diethylbenzamide (BW373U86) for screening against opioid receptors is described. The intermediate α-heterocyclic ben