Chemical and Pharmaceutical Bulletin p. 408 - 409 (1994)
Update date:2022-07-29
Topics:
Achiwa
Shiozawa
Nukaya
Terao
A new mutagen, 2-amino-1,7,9-trimethylimidazo-[4,5-g]quinoxaline (1), isolated from beef extract, was synthesized from 3-fluoro-2-methylaniline via an intermediate, 2,8-dimethyl-7-methylaminoquinoxaline (7a). Its 2- methylanalog (2) was also synthesized from the same intermediate. The synthetic 1 showed the same mutagenic activity as the isolated mutagen. However, 2 was non-mutagenic.
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