Kinetic Mechanism and Reaction Pathway of Thermus thermophilus Isopropylmalate Dehydrogenase

DOI: 10.1021/jo00088a025

Source and publish data:

Journal of Organic Chemistry p. 2423 - 2429 (1994)

Update date:2022-08-05

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Authors:

Pirrung, Michael C.

Han, Hyunsoo

Nunn, David S.

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Article abstract of DOI:10.1021/jo00088a025

Mechanistic studies of isopropylmalate dehydrogenase (IMDH, EC 1.1.1.85), the penultimate enzyme in leucine biosynthesis in bacteria and yeast, have been conducted.It performs two chemical operations, oxidation and decarboxylation, on isopropylmalate to p

Full text of DOI:10.1021/jo00088a025

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