Tetrahedron Letters p. 2369 - 2372 (1994)
Update date:2022-09-26
Topics:
Davies, Stephen G.
Doisneau, Gilles J. -M.
Prodger, Jeremy C.
Sanganee, Hitesh J.
The synthesis of a series of chiral auxiliaries, 5-substituted-3,3-dimethyl-2-pyrrolidinones, "quats", from L-glutamic acid is described. Efficient regeneration of the chiral auxiliaries from their N-pivaloyl derivatives is readily achieved with LiOH in THF-water at 20°C.
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(1994)
