4',6'-Methano carbocyclic thymidine: A conformationally constrained building block for oligonucleotides

DOI: 10.1016/0040-4039(94)85212-X

Source and publish data:

Tetrahedron Letters p. 2331 - 2334 (1994)

Update date:2022-08-03

Topics:

Authors:

Altmann Altmann

Kesselring

Francotte

Rihs Rihs

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Article abstract of DOI:10.1016/0040-4039(94)85212-X

The synthesis of the title compound 1 has been accomplished in 20 chemical steps starting from D-ribonolactone. X-ray crystallography shows the bicyclic skeleton of 1 to adopt a boat-like ('2'-exo') conformation and preliminary hybridization data indicate

Full text of DOI:10.1016/0040-4039(94)85212-X

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