4',6'-Methano carbocyclic thymidine: A conformationally constrained building block for oligonucleotides

Article abstract of DOI:10.1016/0040-4039(94)85212-X

The synthesis of the title compound 1 has been accomplished in 20 chemical steps starting from D-ribonolactone. X-ray crystallography shows the bicyclic skeleton of 1 to adopt a boat-like ('2'-exo') conformation and preliminary hybridization data indicate