Design and synthesis of regioisomeric analogues of a specific anti-HIV-1 agent 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)

Article abstract of DOI:10.1080/15257779408013232

Regioisomeric analogues of the anti-HIV-1 lead 1-[(2- hydroxyethoxy)methyl]-6-(phenylthio)thymine (1: HEPT) have been synthesized. These compounds, having an ethoxymethyl side chain at C-5 and an ethyl group at the N-1 position of the uracil ring, also po

Full text of DOI:10.1080/15257779408013232

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Design and Synthesis of Regioisomeric
Analogues of a Specific Anti-HIV-1
Agent 1-[(2-Hydroxyethoxy)methyl]-6-
(phenylthio)thymine (HEPT)
Hiromichi Tanaka a , Masanori Baba b , Emiko Takahashi a , Kouichiro
Matsumoto a , Atsushi Kittaka a , Richard T. Walker c , Erik De Clercq
d & Tadashi Miyasaka a
a School of Pharmaceutical Sciences, Showa University , Hatanodai
1-5-8, Shinagawa-ku, Tokyo, 142, Japan
b Fukushima Medical College , Fukushima, 960-12, Japan
c School of Chemistry , University of Birmingham , Birmingham, B15
2TT, United Kingdom
d Rega Institute for Medical Research, Katholieke Universiteit
Leuven , B-3000, Leuven, Belgium
Published online: 23 Sep 2006.
To cite this article: Hiromichi Tanaka , Masanori Baba , Emiko Takahashi , Kouichiro
Matsumoto , Atsushi Kittaka , Richard T. Walker , Erik De Clercq & Tadashi Miyasaka (1994)
Design and Synthesis of Regioisomeric Analogues of a Specific Anti-HIV-1 Agent 1-[(2-
Hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT), Nucleosides and Nucleotides, 13:1-3, 155-162,
DOI: 10.1080/15257779408013232
To link to this article: http://dx.doi.org/10.1080/15257779408013232
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