Directed Ortho Metalations of Tertiary Benzamides Using Lactones as Electrophiles

DOI: 10.1016/S0040-4020(01)85024-9

Source and publish data:

Tetrahedron p. 4897 - 4904 (1994)

Update date:2022-07-29

Topics:

Authors:

Brenstrum, Timothy J.

Brimble, Margaret A.

Stevenson, Ralph J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4020(01)85024-9

Directed ortho metalation of oxygenated tertiary benzamides using tert-butyllithium in THF/TMEDA at -78 deg C followed by the addition of a range of lactones afforded ortho-substituted keto-alcohols in good yield.

Full text of DOI:10.1016/S0040-4020(01)85024-9

Products guided by the article

Product name:2,3-dimethoxy-6-(4'-hydroxy-1'-oxobutyl)-N,N-bis-(methylethyl)benzamide

Cas No:156300-84-4

R&D Labs maybe for 156300-84-4

Beijing Mashi Fine Chemical Co.,Ltd.

Contact:+86-10-61271592

Address:Room 506, Section B, Kaichi Mansion, Industrial Development
Changsha Easchem Co.,Limited

website:http://www.easchem.com

Contact:+86-731-89722861 89722891

Address:2/F-4/Bld Colorful Palace, No.605 Changsha Ave, Yuhua Area Changsha Hunan China.
Hangzhou Eastbiopharm Co.,Ltd.

Contact:+86-571-88931780

Address:Hangzhou,China
Phantom-pharma

Contact:

Address:
Zhengzhou Yuanli Biological Technology Co., Ltd.

Contact:+86-371-67897870/67897895

Address:No. 38, Qingyang Street, Zhengzhou, Henan, China

Relevant to this article

Acetals of acid lactams and amides. 76. A new approach to the synthesis of benzofuro[3,2-c]pyridine derivatives

Doi:10.1007/BF02219706
(1996)
Gold-catalyzed annulations of allenes with N-hydroxyanilines to form indole derivatives with benzaldehyde as a promoter

Doi:10.1039/c3ob42131g
(2014)
N-(tert-butoxycarbonyloxy)-5-norbornene-endo-2,3-dicarboximide, a reagent for the regioselective introduction of the tert-butoxycarbonyl (BOC) protective group at unhindered amines: Application to aminoglycoside chemistry

Doi:10.1021/jo00086a055
(1994)
Synthesis of allylnickel aryloxides and arenethiolates. Study of their dynamic isomerization and 1,3-diene polymerization activity

Doi:10.1021/om00017a073
(1994)
Synthesis of the novel pyrrolo[2,1-d][1,2,5]benzotriazepine, pyrrolo[2,1-e][1,3,6]benzotriazocine and pyrrolo[1,2-a]tetrazolo[1,5-d][1,4]benzodiazepine ring systems. A new route to pyrrolo[1,2-a]quinoxaline via transamination of in situ generated 1-(2-aminophenyl)-2-iminomethylpyrroles

Doi:10.1016/0040-4020(96)00597-2
(1996)
Structural and biochemical characterization of the salicylyl-acyltranferase SsfX3 from a tetracycline biosynthetic pathway

Doi:10.1074/jbc.M111.299859
(2011)

Article Doi