Directed Ortho Metalations of Tertiary Benzamides Using Lactones as Electrophiles

DOI: 10.1016/S0040-4020(01)85024-9

Source and publish data:

Tetrahedron p. 4897 - 4904 (1994)

Update date:2022-07-29

Topics:

Authors:

Brenstrum, Timothy J.

Brimble, Margaret A.

Stevenson, Ralph J.

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Article abstract of DOI:10.1016/S0040-4020(01)85024-9

Directed ortho metalation of oxygenated tertiary benzamides using tert-butyllithium in THF/TMEDA at -78 deg C followed by the addition of a range of lactones afforded ortho-substituted keto-alcohols in good yield.

Full text of DOI:10.1016/S0040-4020(01)85024-9

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