Na+-glucose cotransporter inhibitors as antidiabetic agents. III. Synthesis and pharmacological properties of 4'-dehydroxyphlorizin derivatives modified at the OH groups of the glucose moiety

DOI: 10.1248/cpb.46.1545

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1545 - 1555 (1998)

Update date:2022-08-03

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Authors:

Hongu, Mitsuya

Funami, Nobuyuki

Takahashi, Youichi

Saito, Kunio

Arakawa, Kenji

Matsumoto, Mamoru

Yamakita, Hirokazu

Tsujihara, Kenji

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Article abstract of DOI:10.1248/cpb.46.1545

To overcome hydrolysis by β-glucosidase present in the digestive tract, the OH groups on the glucose moiety of the 4'-dehydroxyphlorizin derivatives (1, 2, 3) were modified with various kinds of patterns, and then the effects of the modified compounds on

Full text of DOI:10.1248/cpb.46.1545

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