Synthesis of 13C, 15N-Enriched α-Dicarbonyl Model Adducts to Determine the Utility of 13Cand 15N NMR for Studying Mechanism-Based Inactivation of Cytochromes P-450 by Substituted Dichloroacetamides

DOI: 10.1002/mrc.1260320212

Source and publish data:

Magnetic Resonance in Chemistry p. 122 - 127 (1994)

Update date:2022-08-03

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Authors:

Weiner, Scott J.

Holl, Susan M.

Covey, Douglas F.

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Article abstract of DOI:10.1002/mrc.1260320212

To determine the feasibility of using NMR to study the inactivation of cytochromes P-450 by dichloroacetamide-containing mechanism-based inactivators, 13C,15N-enriched compounds were synthesized, modeling adducts between the nucleophilic side-chain of cys

Full text of DOI:10.1002/mrc.1260320212

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