Synthesis of 13C, 15N-Enriched α-Dicarbonyl Model Adducts to Determine the Utility of 13Cand 15N NMR for Studying Mechanism-Based Inactivation of Cytochromes P-450 by Substituted Dichloroacetamides

Article abstract of DOI:10.1002/mrc.1260320212

To determine the feasibility of using NMR to study the inactivation of cytochromes P-450 by dichloroacetamide-containing mechanism-based inactivators, 13C,15N-enriched compounds were synthesized, modeling adducts between the nucleophilic side-chain of cys