Synthesis of acyclic thieno[3,2-d]pyrimidine nucleosides and azido derivatives as potential anti-HIV agents

Article abstract of DOI:10.1080/15257779408011862

A series of thieno[3,2-d]pyrimidine-2,4-diones alkylated with acyclic chains have been synthesized related to the antiherpetic agents (acyclovir and ganciclovir) and to EBPU which was reported to display in vitro antiviral activity against human immunodeficiency virus type 1 (HIV-1). Conversion of the hydroxy-acyclic nucleosides into their azido derivatives was then examined using triphenylphosphine - carbon tetraiodide - sodium azide. All the compounds, however, did not exhibit any significant inhibitory activity against HIV-1 in CEM cl 13 cells.

Full text of DOI:10.1080/15257779408011862

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Nucleosides and Nucleotides
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Synthesis of Acyclic Thieno[3,2-
d]Pyrimidine Nucleosides and Azido
Derivatives as Potential Anti-HIV Agents
C. Fossey a , D. Laduree a & M. Robba a
a Centre d'Etudes et de Recherche sur le Médicament de Normandie
U.F.R. des Sciences Pharmaceutiques; , 14032, CAEN, CEDEX,
FRANCE
Published online: 24 Sep 2006.
To cite this article: C. Fossey , D. Laduree & M. Robba (1994) Synthesis of Acyclic Thieno[3,2-
d]Pyrimidine Nucleosides and Azido Derivatives as Potential Anti-HIV Agents, Nucleosides and
Nucleotides, 13:4, 883-889, DOI: 10.1080/15257779408011862
To link to this article: http://dx.doi.org/10.1080/15257779408011862
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