A highly selective and efficient access to N-9 alkylated purine derivatives via radical S(RN)1 chemistry

Article abstract of DOI:10.1080/15257779408011886

6-Chloropurine and 2-amino-6-chloropurine were discovered to be efficient nucleophiles in S(RN)1 reactions with various gem halonitroalkane derivatives as substrates to give high yield of N-9 alkylated purine derivatives in a N- 9/N-7 ratio greater than 9

Full text of DOI:10.1080/15257779408011886

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Nucleosides and Nucleotides
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A Highly Selective and Efficient Access
to N-9 Alkylated Purine Derivatives via
Radical SRN1 Chemistry
Tawfik Gharbaoui a , Rachid Benhida a , André Lechevallier a , Phillip
Maillos a & René Beugelmans a
a Institut de Chimie des Substances Naturelles, CNRS , Gif sur
Yvette, 91190, France
Published online: 24 Sep 2006.
To cite this article: Tawfik Gharbaoui , Rachid Benhida , André Lechevallier , Phillip Maillos
& René Beugelmans (1994) A Highly Selective and Efficient Access to N-9 Alkylated Purine
Derivatives via Radical SRN1 Chemistry, Nucleosides and Nucleotides, 13:5, 1161-1168, DOI:
10.1080/15257779408011886
To link to this article: http://dx.doi.org/10.1080/15257779408011886
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