Synthesis and biologic evaluation of 8-substituted derivatives of nebularine (9-β-D-ribofuranosylpurine)

Article abstract of DOI:10.1080/15257779408011875

A series of 8-substituted purine ribonucleosides were prepared from 2',3',5'-tri-O-acetyl-8-bromoadenosine and evaluated for cytotoxicity and antiviral activity. Four of these nucleosides (6b-9b) were significantly toxic to both HEp-2 and L1210 cells in culture but the most cytotoxic one (9b) was inactive against the P388 leukemia in mice. None of these nucleosides showed significant antiviral activity against Herpes Simplex 1 or 2, vaccinia, or influenza A.

Full text of DOI:10.1080/15257779408011875

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Synthesis and Biologic Evaluation of 8-
Substituted Derivatives of Nebularine
(9-β-D-Ribofuranosylpurine)
John A. Secrist III a , Anita Shortnacy-Fowler a , L. Lee Bennett Jr. a
& John A. Montgomery a
a Southern Research Institute , P. O. Box 55305, Birmingham, AL,
35255-5305
Published online: 24 Sep 2006.
To cite this article: John A. Secrist III , Anita Shortnacy-Fowler , L. Lee Bennett Jr. & John
A. Montgomery (1994) Synthesis and Biologic Evaluation of 8-Substituted Derivatives of
Nebularine (9-β-D-Ribofuranosylpurine), Nucleosides and Nucleotides, 13:5, 1017-1029, DOI:
10.1080/15257779408011875
To link to this article: http://dx.doi.org/10.1080/15257779408011875
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