Discovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections

DOI: 10.1016/j.bmc.2014.01.020

Source and publish data:

Bioorganic and Medicinal Chemistry p. 1708 - 1725 (2014)

Update date:2022-09-26

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Authors:

Kumar, Nag S.

Dullaghan, Edie M.

Finlay, B. Brett

Gong, Huansheng

Reiner, Neil E.

Jon Paul Selvam

Thorson, Lisa M.

Campbell, Sara

Vitko, Nicholas

Richardson, Anthony R.

Zoraghi, Roya

Young, Robert N.

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Article abstract of DOI:10.1016/j.bmc.2014.01.020

A novel series of bis-indoles derived from naturally occurring marine alkaloid 4 were synthesized and evaluated as inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase (PK). PK is not only critical for bacterial survival which

Full text of DOI:10.1016/j.bmc.2014.01.020

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