C-fluorinated phosphate analogues

Article abstract of DOI:10.1016/0022-1139(93)02990-V

C-fluorinated phosphinic acid derivatives RP(O)(OEt)CF2Br (R = Ph, Me) 2a, b and 1)>2CF2 (R = Ph, R¹ = Et, H) 3, 4 have been prepared via a Michaelis-Arbuzov reaction.The signs of the scalar coupling constants in the AMX spin system of (EtO)2P(O)CHFCOOEt (5) formed by the P, F and H of the P-C(H)F unit were determined using spin-tickling techniques.