Journal of Organic Chemistry p. 4862 - 4867 (1994)
Update date:2022-07-30
Topics:
Guzzo, Peter R.
Miller, Marvin J.
A catalytic, asymmetric synthesis of the carbacephem β-lactam framework is reported.The initial asymmetric center was established by catalytic hydrogenation of β-keto ester 12 with (S)-Ru-BINAP.The β-lactam ring was prepared using the hydroxamate approach (14 -> 15).The nitrogen substituent at C7 was introduced by the nucleophile transfer reaction (15 -> 17), and the six-membered ring of the carbacephem was prepared by a directed Dieckmann condensation (24 -> 25).
View MoreShanghai Sinofluoro Scientific Co., Ltd
Contact:+86-21-64279360
Address:Room 1006,Building 3,#58 East Xinjian Road, Shanghai ,201100,China,
Jining tiansheng chemical co.,ltd.
Contact:+86-537-5158722
Address:ROOM 1011, BLOCK B, CUIDU INTERNATIOAL BUSINESS CENTER, JINING CITY, CHINA
hangzhou verychem science and technology co.ltd
website:http://www.verypharm.com
Contact:+86-571-88162785; 88162786
Address:F1502, 753 Shenhua road, Hangzhou, China
Contact:+ 86 512 52491118
Address:1 Fuyu Road, Haiyu TownChangshu, Jiangsu, China
shijiazhuang shuanglian chemical industry co.,ltd
Contact:0311-82190302
Address:Luquan Intersection , Shijiazhuang--Taiyuan Expressway，Shijiazhuang City
Doi:10.1021/om5000908
(2014)Doi:10.1039/DT9940002339
(1994)Doi:10.1021/bc400486w
(2014)Doi:10.1021/jo500281h
(2014)Doi:10.1021/jo00100a012
(1994)Doi:10.1016/j.tetlet.2014.02.028
(2014)
