Novel prodrugs of alkylating agents derived from 2-fluoro- and 3- fluorobenzoic acids for antibody-directed enzyme prodrug therapy

DOI: 10.1021/jm00041a015

Source and publish data:

Journal of Medicinal Chemistry p. 2361 - 2370 (1994)

Update date:2022-07-29

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Authors:

Springer

Niculescu-Duvaz

Pedley Pedley

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Article abstract of DOI:10.1021/jm00041a015

The synthesis of six novel fluorinated potential prodrugs for antibody- directed enzyme prodrug therapy is described. The [2- and 3-fluoro-4-[bis(2- chloroethyl)amino]benzoyl]-L-glutamic acid (9 and 21), their bis(mesyloxy)ethyl derivatives (7 and 19), an

Full text of DOI:10.1021/jm00041a015

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