Synthesis of -tamoxifen; A Mechanistic Probe of Tamoxifen Induced Hepatic DNA Adduct Formation

DOI: 10.1002/jlcr.2580340810

Source and publish data:

Journal of labelled compounds and radiopharmaceuticals p. 767 - 772 (1994)

Update date:2022-09-26

Topics: Synthesis Mechanistic probe hepatic

Authors:

Horton, Martin N.

Jarman, Michael

Potter, Gerard A.

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Article abstract of DOI:10.1002/jlcr.2580340810

Tamoxifen which incorporates a fully deuterated ethyl group, 5-ethyl>-tamoxifen, has been synthesised in order to probe the mechanism of tamoxifen induced hepatic DNA adduct formation.The pentadeuteroethyl group was introduced into the tamoxi

Full text of DOI:10.1002/jlcr.2580340810

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