A rapid, highly efficient, and general protocol for the synthesis of functionalized triarylmethanes: A straightforward access for the synthesis of (-)-tatarinoid C

Article abstract of DOI:10.1016/j.tetlet.2014.01.107

A rapid, efficient, and convenient synthesis of functionalized triarylmethane is described by the Friedel-Crafts alkylation of methoxybenzenes with a variety of aldehydes in the presence of BF₃·OEt ₂. The generality of the method is demonstrated by screening a variety of di- or tri-substituted arenes as well as substituted aromatic, heteroaromatic, and aliphatic aldehydes. (-)-Tatarinoid C is synthesized in a single step following the same protocol.