Synthesis of Novel Phosphonate Analogue of Kdo as a Tool for the Design of Potent Inhibitors for Lipopolysaccharide Biosynthesis

Article abstract of DOI:10.1016/S0040-4039(00)73325-9

The new phosphonate analogue 3 of 2-deoxy-β-Kdo (2) was prepared in a stereospecific manner via intramolecular C-C bond formation.X-Ray structure analysis and NMR studies of the cyclyzation product established the twist-boat conformation of the pyranose ring with α-anomeric configuration of the phosphonate linkage.