Synthesis of Novel Phosphonate Analogue of Kdo as a Tool for the Design of Potent Inhibitors for Lipopolysaccharide Biosynthesis

DOI: 10.1016/S0040-4039(00)73325-9

Source and publish data:

Tetrahedron Letters p. 5077 - 5080 (1994)

Update date:2022-08-02

Topics:

Authors:

Sheffer-Dee-Noor, Shani

Belakhov, Valery

Baasov, Timor

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Article abstract of DOI:10.1016/S0040-4039(00)73325-9

The new phosphonate analogue 3 of 2-deoxy-β-Kdo (2) was prepared in a stereospecific manner via intramolecular C-C bond formation.X-Ray structure analysis and NMR studies of the cyclyzation product established the twist-boat conformation of the pyranose ring with α-anomeric configuration of the phosphonate linkage.

Full text of DOI:10.1016/S0040-4039(00)73325-9

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