Syntheses of the lower portions of the pamamycins from γ-(silyloxy)allenes using stereselective cyclization, reduction, and aldehyde addition methodologies

Article abstract of DOI:10.1021/jo00091a037

The pamamycins are a group of homologous macrodiolides produced by Streptomyces alboniger and Streptomyces aurantiacus JA 4570 which are remarkable for their autoregulatory, antifungal, antibacterial, and anion-transferring activities. The syntheses of th