Synthesis and Opioid Activity of 7-Oxygenated 2,3,4,4a,5,6,7,7a-Octahydro-1H-benzofuroisoquinolin-9-ols

Article abstract of DOI:10.1021/jm00045a017

3-(Cyclopropylmethyl)-9-hydroxy-7-oxo-2,3,4,4aα,5,6,7,7aα-octahydro-1H-benzofuro<3,2-e>isoquinoline (4b) containing the ACNO ring system of morphine and a 7-keto function on ring C has been synthesized and found to possess potent PQW (ED50 = 0.15 mg/kg sc