Synthesis and Opioid Activity of 7-Oxygenated 2,3,4,4a,5,6,7,7a-Octahydro-1H-benzofuroisoquinolin-9-ols

DOI: 10.1021/jm00045a017

Source and publish data:

Journal of Medicinal Chemistry p. 3121 - 3127 (1994)

Update date:2022-07-31

Topics:

Authors:

Cheng, Chen-Yu

Hsin, Ling-Wei

Tsai, Ming-Cheng

Shmidt, William K.

Smith, Christine

Tam, S. William

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Article abstract of DOI:10.1021/jm00045a017

3-(Cyclopropylmethyl)-9-hydroxy-7-oxo-2,3,4,4aα,5,6,7,7aα-octahydro-1H-benzofuro<3,2-e>isoquinoline (4b) containing the ACNO ring system of morphine and a 7-keto function on ring C has been synthesized and found to possess potent PQW (ED50 = 0.15 mg/kg sc

Full text of DOI:10.1021/jm00045a017

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