Synthesis of Protected 4-Oxopipecolic Acid and 4-Oxolysine using a Palladium-catalysed Coupling Process

Article abstract of DOI:10.1016/S0040-4039(00)73372-7

Reaction of the L-serine derived zinc reagent 3 with acryloyl chloride gave 4-oxo amino acid 4, with no evidence of products arising from conjugate addition.Treatment of the adduct 4 with benzylamine gave protected 4-oxolysine 5 directly.Reduction of the