Catalytic Asymmetric Reductive Addition of Olefins to Aldehydes Mediated by Boron and Zinc Organometallics

DOI: 10.1016/0040-4039(94)88412-9

Source and publish data:

Tetrahedron Letters p. 9007 - 9010 (1994)

Update date:2022-08-03

Topics:

Authors:

Schwink, Lothar

Knochel, Paul

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(94)88412-9

A procedure involving a hydroboration, boron-zinc exchange and asymmetric addition to an aldehyde allows the reductive addition of olefins to aldehydes in 50-96percent ee.A short and efficient 3 step synthesis of ginnol (61percent overall yield, 92percent ee) demonstrates the synthetic utility of the method.

Full text of DOI:10.1016/0040-4039(94)88412-9

Products guided by the article

Product name:(R)-5-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-pentan-1-ol

Cas No:158197-51-4

R&D Labs maybe for 158197-51-4

Ningbo Tide Imp. & Exp. Co., Ltd.

Contact:+86-571-8993 7933; +86-571-8993 6453

Address:7/F Anno Domini Building, Tower South, 8 Qiu Shi Road,Hangzhou,China.
SHANXI XINTIANYUAN PHARMACEUTICAL CO., LTD.

website:http://www.tychemical.com

Contact:0086-358-3521713 3521715

Address:No. 1 Yintong Road, Shanxi Jiaocheng Economic Development Zone, Xiajiaying Town, Jiaocheng County, Lvliang City, Shanxi Province, China
Lanzhou SchiffChem Co.,Ltd

Contact:86-931-8272767

Address:Room 602, No.461, Nanchang Road, Chengguan District, Lanzhou City, China PRC
NANCHANG QINZHI SCI&TEC.CO.,LTD(expird)

Contact:+86-13687004106

Address:Hero South Road,Hero Zone,Nanchang,Jiangxi,China
Anhui Dexinjia Biopharm Co., Ltd

Contact:+86-531-82375818

Address:9 Hexie Road, kaifaqu, Taihe

Relevant to this article

Rigidity versus Flexibility: Is This an Issue in σ₁ Receptor Ligand Affinity and Activity?

Doi:10.1021/acs.jmedchem.6b00585
(2016)
Doi:10.1016/0020-1693(94)03917-8
(1994)
Discovery of nitropyridine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors via a structure-based core refining approach

Doi:10.1016/j.ejmech.2014.02.047
(2014)
Regioselective synthesis of 5-unsubstituted benzyl pyrrole-2-carboxylates from benzyl isocyanoacetate

Doi:10.1002/jhet.5570310402
(1994)
Transformation of the Bis(trimethylsilyl)methyl into a β-Diketinimato Ligand; the X-Ray Structure of , and ,

Doi:10.1039/c39940001699
(1994)

Stereoselective synthesis of 1,3-amino alcohols by the Pd-catalyzed cyclization of trichloroacetimidates

Doi:10.1021/jo402681z
(2014)

Article Doi