Regioselective synthesis of 5-unsubstituted benzyl pyrrole-2-carboxylates from benzyl isocyanoacetate

DOI: 10.1002/jhet.5570310402

Source and publish data:

Journal of Heterocyclic Chemistry p. 707 - 710 (1994)

Update date:2022-08-03

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Authors:

Ono Ono

Katayama

Nisyiyama

Ogawa Ogawa

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Article abstract of DOI:10.1002/jhet.5570310402

A general synthesis of 5-unsubstituted benzyl pyrrole-2-carboxylates was developed based on the reaction of β-nitroacetates with benzyl isocyanoacetate. The advantage of this route over other pyrrole syntheses was the regiochemical control of the substitution pattern on the pyrrole ring.

Full text of DOI:10.1002/jhet.5570310402

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