Asymmetric Synthesis. 32. A New Access to Enantiomerically Pure (S)-(-)-Pipecolic Acid and 2- or 6-Alkylated Derivatives

DOI: 10.1021/jo00093a007

Source and publish data:

Journal of Organic Chemistry p. 3769 - 3774 (1994)

Update date:2022-09-26

Topics:

Authors:

Berrien, J. -F.

Royer, J.

Husson, H. -P.

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Article abstract of DOI:10.1021/jo00093a007

Enantiomerically pure (S)-(-)-pipecolic acid (5) was synthesized in four steps and 47percent overall yield starting from 2-cyano-6-phenyloxazolopiperidine (1).A general strategy is described for preparing 2-alkylated and 6-alkylated pipecolic acid 7a-c and 11a-c using diastereoselective procedures.

Full text of DOI:10.1021/jo00093a007

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