Synthesis of Chiral Urethane N-Alkoxycarbonyl Tetramic Acids from Urethane N-Carboxyanhydrides (UNCAs)

DOI: 10.1016/S0040-4039(00)76757-8

Source and publish data:

Tetrahedron Letters p. 1557 - 1560 (1994)

Update date:2022-08-05

Topics:

Authors:

Fehrentz, Jean-Alain

Bourdel, Elisabeth

Califano, Jean-Christophe

Chaloin, Oliveir

Devin, Chantal

et al. et al.

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Article abstract of DOI:10.1016/S0040-4039(00)76757-8

The synthesis of chiral N-protected tetramic acid derivatives which are precursors of β-hydroxy γ-amino acid under mild conditions is described.Reaction of urethane-N-carboxyanhydrides (UNCAs) with Meldrum's acid in the presence of a tertiary amine, follo

Full text of DOI:10.1016/S0040-4039(00)76757-8

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