Tetrahedron Letters p. 2451 - 2453 (2001)
Update date:2022-08-04
Topics:
Sun, Hongbin
Yang, Jingsong
Amaral, Katie E.
Horenstein, Benjamin A.
A new class of glycosyltransferase inhibitor has been designed and synthesized. The designed inhibitors 3a/3b provide conformational mimicry of the transition state in sialyltransfer reactions. The key synthetic steps involve a Meinwald rearrangement and a palladium-catalyzed carbonylation reaction. The results of kinetic studies show that 3a/3b exhibit significant inhibition on both 2,3- and 2,6-sialytransferases.
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Doi:10.1016/0020-1693(94)03925-9
(1994)Doi:10.2174/157017811795371421
(2011)Doi:10.1016/j.tet.2014.02.030
(2014)Doi:10.1016/0040-4039(91)80438-C
(1991)Doi:10.1002/anie.200902065
()Doi:10.1055/s-1998-2031
(1998)