Tetrahedron Letters p. 4091 - 4092 (1994)
Update date:2022-07-29
Topics:
Mueller, Rudolf
Revesz, Laszlo
The first short synthesis of the dipeptide mimetic (3S,6S,9S)-6-amino-5-oxoindolizidine-3-carboxylic acid 1 and its Z-protected derivative 9 is described, employing the Schoellkopf bislactim-ether methodology, followed by a highly specific intramolecular reductive amination and spontaneous lactamization.These 6,5-fused bicyclic lactams may be viewed as comformationally restricted alanyl-proline β-turn mimetics.
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