Tetrahedron Asymmetry p. 921 - 926 (1994)
Update date:2022-09-26
Topics:
Ezquerra
Pedregal
Mico
Najera
4-Methylene-L-glutamic acid (1) and its cyclopropyl analogue 2 were obtained from ethyl N-Boc-pyroglutamate (3) in 2 and 3 steps, respectively. The key intermediate, ethyl N-Boc-4-methylenepyroglutamate (4) was prepared by reaction of the lithium lactam e
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