European Journal of Medicinal Chemistry p. 381 - 388 (1994)
Update date:2022-09-26
Topics:
Caliendo, G.
Cirino, G.
Greco, G.
Novellino, E.
Perissutti, E.
et al.
A set of 1-methyl-2-(4-X-benzoyl)imidazole-5-acetic acids that are structurally related to tolmetin and zomepirac were synthesized and biologically evaluated for their antiinflammatory activity.The results of in vivo tests and enzymatic assays showed that some of the investigated compounds are characterized by an analgesic-antiinflammatory profile similar or better than that of tolmetin.Preliminary structure-activity relationships suggest that activity is promoted by electron-releasing substituents in the para-position of the benzoyl moiety. imidazole / analgesic-antiinflammatory activity / cyclooxygenase / SAR
View MoreHebei Think-Do Environment Co., Ltd
website:http://www.thinkdo-environment.com
Contact:0311-86510809-
Address:No 6, Shilian Middle Street, Circular Chemical Industry Park
Nanjing Chemical Material Corp.(NCMC)
website:http://www.njchemm.com
Contact:0086-25-83172879
Address:B12 Technology and Innovation Building, Nanjing Tech University, No.5 New Model Road
Suzhou Wedo Chemicals Co., Ltd.
Contact:86 512 58100425
Address:Zonger Road, DongSha Industry Park , Zhangjiagang, Jiangsu, China
Contact:021-36356756
Address:Room601,Building No.14,280 Yangcheng Road,Shanghai
Nanjing Spring & Autumn Biological Engineering Co., Ltd.
Contact:86-180510-83338
Address:Suite# 210, No. 1 BuildingNanjing Agricultural Biotechnology High-tech Entrepreneurship Center, No. 4 Tongwei Road, Xuanwu District, Nanjing,China
Doi:10.1055/s-0029-1218640
(2010)Doi:10.1002/jhet.3593
(2019)Doi:10.1016/S0008-6215(00)82812-8
(1974)Doi:10.1002/ejoc.201501306
(2016)Doi:10.1016/j.ica.2010.02.007
(2010)Doi:10.1016/j.bmcl.2010.03.058
(2010)
