European Journal of Medicinal Chemistry p. 381 - 388 (1994)
Update date:2022-09-26
Topics:
Caliendo, G.
Cirino, G.
Greco, G.
Novellino, E.
Perissutti, E.
et al.
A set of 1-methyl-2-(4-X-benzoyl)imidazole-5-acetic acids that are structurally related to tolmetin and zomepirac were synthesized and biologically evaluated for their antiinflammatory activity.The results of in vivo tests and enzymatic assays showed that some of the investigated compounds are characterized by an analgesic-antiinflammatory profile similar or better than that of tolmetin.Preliminary structure-activity relationships suggest that activity is promoted by electron-releasing substituents in the para-position of the benzoyl moiety. imidazole / analgesic-antiinflammatory activity / cyclooxygenase / SAR
View MoreContact:86 311 85902108 / 85902109
Address:room 1001-1005 ,huanghe Road ,shijiazhuang ,China
Contact:0091-265-2313036
Address:311, ATLANTIS HEIGHTS SARABHAI MAIN ROAD,VADIWADI ,VADODARA
Taizhou Sunny Chemical Co.,Ltd
Contact:+86-523-86920899 +86-13951172783
Address:No.11 Xingyuang road, Gaoyong Chemical Industry Park, Gaogang Jiangsu China
Contact:0086-357-6662688
Address:Zhaocheng town, Hongtong County, Linfen City, Shanxi Province
Jiaxing Trustworthy Import And Export Co.,Ltd
Contact:+86-573-82030555
Address:Room 1202, Unit B, Charming plaza,No.1558 East Zhongshan Road , Jiaxing City, Zhejiang Province, China.
Doi:10.1055/s-0029-1218640
(2010)Doi:10.1002/jhet.3593
(2019)Doi:10.1016/S0008-6215(00)82812-8
(1974)Doi:10.1002/ejoc.201501306
(2016)Doi:10.1016/j.ica.2010.02.007
(2010)Doi:10.1016/j.bmcl.2010.03.058
(2010)
