Mechanism of alkaline cyclization of 2-(substituted benzamido)benzamides to 4-quinazolinones

Article abstract of DOI:10.1021/jo00100a026

The title amides cyclize rapidly to the corresponding quinazolin-4-ones in aqueous alkaline solution at 25°C; the pseudo-first-order rate constants fit the empirical equation k(obs) = k(max) [OH^-]/(K(m) + [OH^-] + [OH^-]