A Total Synthesis of (-)-α-Kainic Acid Involving a Pauson-Khand Reaction as the Key Step

Article abstract of DOI:10.1021/jo00102a021

A synthetic route to (-)-α-kainic acid has been developed based on the Pauson-Khand reaction as a key step for the construction of the bicyclic ring system.In this reaction a built-in oxazolidinone ring serves as a rigid template for good diastereofacial selectivity.