Saponification agents. 2. Synthesis of arylisocyanates with ethyl lactate and their use in racemic bases saponification

Article abstract of DOI:10.1016/S0040-4020(01)81763-4

Reaction of the arylisocyanates 2a-c with ethyl (S)-(-)-lactate, followed by careful saponification, afforded the corresponding chiral acids (S)-(-)- 4a-c. The latter were successfully used for the resolution of various racemic bases belonging to both the ephedrine and α-aryl ethylamine series.