Diastereospecific synthesis of 2′- or 3′-c-branched nucleosides through intramolecular free-radical capture by silicon-tethered acetylene

Article abstract of DOI:10.1016/S0040-4020(01)90435-1

The intramolecular free-radical trapping by a silicon tethered acetylene function in a ribonucleoside 2a, 2b, 2c, 8a, 8b or 8c gave only the [3.3.0]-cis-fused Z-vinylsiloxane 3a, 3b, 3c, 9a, 9b or 9c (>90%) in a diastereospecific manner. The temporary sil